Genopathy
Gene-Disorder Association · Article
Gene
ZFHX3
Zinc Finger Homeobox 3
Disorder
Prostate Cancer
First reported 2005
Supporting publications 3
Key publication · gene–disorder Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer.Nature genetics · 2005
Key publication · disorder Endocrine control of prostatic carcinoma; clinical and statistical survey of 1,818 cases.Journal of the American Medical Association · 1950
Manually curated
Association Review

In brief

The association between ZFHX3 (Zinc Finger Homeobox 3) and Prostate Cancer is a manually-curated gene–disease association, with its 2 contributing sources — 1 of them expert-curated — recording a known molecular basis.

Sources 2
Clinical variants 0
Symptoms 5
Compounds 0
Trials 0
Publications 3
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

2 sources

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
ZFHX3

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

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04
Prostate Cancer

The disorder

20 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
Phenotype

Clinical features

1 clinical feature

The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.

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06
Population genetics

GWAS signals

1 GWAS phenotype

Gene-associated GWAS phenotypes matching the disorder, with best SNP, score, risk-allele frequency and effect size.

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07
Mechanism overlap

Shared mechanisms

Biological pathways and phenotype concepts shared by the gene and the disorder, with supporting publications.

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08
Literature

Reading

3 publications

Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.

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09
Provenance

References & sources

10 references

Every source and publication cited across this dossier, as one numbered reference list.

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