Genopathy
Gene-Disorder Association · Article
Gene
ZFYVE26
Zinc Finger FYVE-Type Containing 26
Disorder
Spastic Paraplegia 15, Autosomal Recessive
First reported 2001
Supporting publications 14
Key publication · gene–disorder SPG15, a new locus for autosomal recessive complicated HSP on chromosome 14q.Neurology · 2001
Key publication · disorder Familial spastic paraplegia with amyotrophy, oligophrenia, and central retinal degeneration.Archives of neurology · 1959
Manually curated
Association Review

In brief

The association between ZFYVE26 (Zinc Finger FYVE-Type Containing 26) and Spastic Paraplegia 15, Autosomal Recessive is well established and manually curated, with its 4 contributing sources — 3 of them expert-curated — recording a known molecular basis, pathogenic variants, and a causative germline mutation.

Sources 4
Clinical variants 469
Symptoms 75
Compounds 0
Trials 0
Publications 14
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

Request access
02
Provenance

Evidence and sources

4 sources

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

Request access
03
ZFYVE26

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

Request access
04
Spastic Paraplegia 15, Autosomal Recessive

The disorder

11 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

Request access
05
Phenotype

Clinical features

54 clinical features

The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.

Request access
06
ClinVar and variant evidence

Genetic basis

469 clinical variants

ClinVar variants reported for this pair, with disorder-specific significance, review status, molecular consequence and origin.

Request access
07
Mechanism overlap

Shared mechanisms

Biological pathways and phenotype concepts shared by the gene and the disorder, with supporting publications.

Request access
08
Literature

Reading

14 publications

Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.

Request access
09
Provenance

References & sources

16 references

Every source and publication cited across this dossier, as one numbered reference list.

Request access